Peripheral 5-HT is produced and secreted by the enterochromaffin cells in the gastrointestinal tract where it regulates intestinal mobility
Although we focused on non-diabetic individuals with overweight and obesity, potential confounding factors such as concomitant medications, baseline gastrointestinal conditions, and varying lifestyle factors could have influenced the incidence and severity of reported adverse events
Evidence-based alternatives include optimising nutrition with iron-rich foods and complex carbohydrates, taking recommended supplements such as vitamin D (10 micrograms daily), addressing iron deficiency if confirmed by blood tests, ensuring adequate hydration, and prioritising sleep when possible
l-carnitine protects against DNA damage caused by the harmful effects of free radicals and maintains a moderate concentration ratio of low acetyl-CoA/CoA [48]
15 The prohibition against producing drugs that are essentially copies of approved products protects the integrity and effectiveness of the new drug and abbreviated new drug approval processes
Nencioni et al., 2003)